Digital library access for illiterate users

The problems that illiteracy poses in accessing information are gaining attention from the research community. Issues currently being explored include developing an understanding of the barriers to information acquisition experienced by different groups of illiterate information seekers; creating technology, such as software interfaces, that support illiterate users effectively; and tailoring content to increase its accessibility. We have taken a formative evaluation approach to developing and evaluating a digital library interface for illiterate users. We discuss modifications to the Greenstone platform, describe user studies and outline resulting design implications

Perfis associados ao consumo de álcool em adolescentes colombianos

El consumo de alcohol en adolescentes tiene una serie de consecuencias negativas desde el punto de vista de salud, comportamiento y riesgo de consumo problemático a edades tempranas. En este estudio, se aplicó un instrumento de 24 preguntas a 9348 estudiantes de ambos sexos en nueve ciudades de Colombia, de los cuales 7625 fueron incluidos en este análisis por haber consumido alcohol. Específicamente, se exploraron temas como la edad de inicio de consumo, el tipo de alcohol y las cantidades ingeridas, así como los sitios y la facilidad de adquisición, la presencia de adultos, el consumo en el colegio y las actitudes frente a las restricciones legales, entre otros. Se hizo un análisis de correspondencias múltiples que determinó inicialmente tres factores que fueron después clasificados en dos grupos y, por último, en cuatro subgrupos en función de cuatro categorías de consumo: experimental, selectivo, regular y alto, que representan dos grandes grupos: bajo y alto consumo. De este análisis surgieron per les bastante claros que muestran diferencias importantes, especialmente entre dos grupos: los de bajo consumo, que son los más jóvenes, no toman solos, no han estado en fiestas con alcohol, nunca toman en el colegio ni durante varios días seguidos; y los de alto consumo, que son un poco mayores, cuando toman se emborrachan, tienden a tomar todas las semanas, han tomado en el colegio y antes de entrar por las mañanas, se han metido en problemas por tomar y rechazan las restricciones a los menores de edad o que se sancione a quienes les venden.Alcohol abuse in adolescents has several negative consequences on health, behavior and risk of becoming involved in problematic consumption at early ages. In this study a 24-item questionnaire was answered by 9,348 school adolescents of both sexes in nine Colombian cities. 7,625 students were included in this analysis due to their consumption of alcohol. The questions inquired about age of first intake, kind and amounts of alcohol consumed on each occasion, places and availability, presence of adults, alcohol use at school and attitudes toward legal restrictions, among others. A multiple correspondence analysis was carried out, generating four factors which were condensed later into two groups, and finally in four sub-groups based on categories of alcohol use: experimental, selective, regular and high, representing two categories: low and high use. The analysis produced identifiable profiles, quite different especially for two categories: the ‘low consumption’ group, that is younger, never drinks alone, does not attend parties where alcohol is offered to minors, has never drunk at school or during several days. In the ‘high consumption’ group are those over 16 years of age, who generally get drunk when they drink, have taken alcohol while at school and before arriving to school, have been in trouble because of alcohol and consider as inappropriate the legal restrictions to minors and the sanctions imposed to adults who sell or offer alcohol to minors

Using positive deviance in the prevention and control of MRSA infections in a Colombian hospital: a time-series analysis

Positive Deviance (PD) is a process to achieve a social and cultural change. This strategy has been used for the control of methicillin-resistant Staphylococcus aureus (MRSA) infection in some health institutions in the United States, but has rarely been adopted in institutions from developing countries where resources are limited. We describe our experience of PD in the control of healthcare-associated infections (HAIs) due to MRSA in a Colombian hospital with the aim of reducing HAI rates through a cultural change in processes. A time-series study was conducted based on the MRSA-HAI rate and the number of months with zero MRSA infections before and after application of PD (2001-2012). On comparing the pre-intervention and intervention periods, the mean overall rates of MRSA-HAI was 0·62 and 0·36, respectively (P = 0·0005); the number of months with zero MRSA-HAIs were 3/70 and 12/74 (odds ratio 0·264, 95% confidence interval 0·078-0·897); the percentage of MRSA-HAIs was 53·2% and 41·0%. These results are consistent with other published data. Implementation of PD was associated with a significant reduction of MRSA-HAIs, it did not involve high costs and the changes have been lasting

BK virus associated meningoencephalitis in an AIDS patient treated with HAART

A severely immune-suppressed AIDS patient was suspected of suffering from BK virus (BKV) meningoencephalitis, after being studied for common causes of neurological complications of co-infectious origin. Polymerase chain reaction (PCR) and sequence analysis of cerebrospinal fluid and brain samples, confirmed the presence of BKV. His clinical condition improved along with the regression of brain lesions, after modifications on his antiretroviral regime. Five months after discharge, the patient was readmitted because of frequent headaches, and a marked inflammatory reaction was evidenced by a new magnetic resonance imaging (MRI). The symptoms paralleled a rising CD4+ lymphocyte count, and immune reconstitution syndrome was suspected. This is the first non-postmortem report of BKV meningoencephalitis in an AIDS patient, showing clinical and radiographic improvement solely under HAART

Comparing families of dynamic causal models

Mathematical models of scientific data can be formally compared using Bayesian model evidence. Previous applications in the biological sciences have mainly focussed on model selection in which one first selects the model with the highest evidence and then makes inferences based on the parameters of that model. This “best model” approach is very useful but can become brittle if there are a large number of models to compare, and if different subjects use different models. To overcome this shortcoming we propose the combination of two further approaches: (i) family level inference and (ii) Bayesian model averaging within families. Family level inference removes uncertainty about aspects of model structure other than the characteristic of interest. For example: What are the inputs to the system? Is processing serial or parallel? Is it linear or nonlinear? Is it mediated by a single, crucial connection? We apply Bayesian model averaging within families to provide inferences about parameters that are independent of further assumptions about model structure. We illustrate the methods using Dynamic Causal Models of brain imaging data

Linfoma de células T/natural killer extranodal de tipo nasal enmascarado en una sinusopatía

Introducción: El linfoma de células T citotóxico/natural killer extranodal de tipo nasal es poco frecuente, pero con alta tasa de mortalidad. Las manifestaciones clínicas de la enfermedad pueden simular una infección de senos paranasales. Objetivo: Presentar las manifestaciones clínicas de un paciente de 34 años de edad con diagnóstico de linfoma de células T citotóxico/ natural killer extranodal de tipo nasal. Caso clínico: Se presenta un paciente masculino de 34 años de edad con rinorrea verdosa fétida recurrente y obstrucción en fosa nasal derecha. En la evaluación inicial sugiere sinusitis crónica, sin embargo, debido al empeoramiento de las manifestaciones clínicas se realiza una tomografía computarizada que muestra lesiones sugestivas de infiltración neoplásica, una biopsia de la lesión confirma el diagnóstico de linfoma de células T/natural killer extranodal de tipo nasal. Conclusiones: Los linfomas de células T citotóxico/natural killer extranodal de tipo nasal son considerados neoplasias poco frecuentes, caracterizadas por el patrón rápidamente progresivo con afectación ósea; en su etapa inicial presenta manifestaciones clínicas similares a una sinusitis. La tomografía computarizada y la histopatología, son indispensables en el diagnóstico de la enfermedad